Cancer Detection (Biopsy, CT, MRI) and Treatment (Surgery, Radiation, Chemotherapy)

Biology · Human Health and Diseases · NEET

Cancer is detected by biopsy (looking at a tissue piece under a microscope), blood and bone marrow tests, and imaging like radiography (X-ray), CT and MRI. It is treated by surgery, radiation therapy and chemotherapy, and by α-interferon, a biological response modifier that boosts the patient's own immune system. Memory hook: "Detect = Biopsy + CT/MRI; Treat = Surgery + Radiation + Chemo (S-R-C)."
Cancer: Detection and TreatmentDETECTIONBiopsy + histopathology (microscope)Blood/bone marrow test (leukemia: count up)CT = X-rays, 3D imageMRI = magnetic field, non-ionisingAntibodies vs cancer antigensTREATMENTSurgery (remove tumor)Radiotherapy (irradiate tumor cells)Chemotherapy (drugs kill cancer cells)Immunotherapy: α-interferon (BRM)Most cancers = combination of all three
Cancer detection relies on biopsy, blood/bone-marrow tests and CT/MRI imaging; treatment combines surgery, radiotherapy, chemotherapy and immunotherapy (α-interferon).

Your doubts, answered

What is biopsy and why is it used first to detect cancer?

In biopsy, a piece of the suspected tissue is cut into thin sections, stained, and examined under a microscope by a pathologist. This is called histopathological study. It confirms whether the cells are cancerous, so NEET treats biopsy as the basic, most direct detection method.

Do CT and MRI both detect cancer of internal organs?

Yes. NCERT clearly says radiography (X-rays), CT (computed tomography) and MRI (magnetic resonance imaging) are very useful to detect cancers of the internal organs. This exact line was tested in NEET 2025, so remember both CT and MRI are correct.

What is the difference between CT and MRI in cancer detection?

CT (computed tomography) uses X-rays to make a three-dimensional image of the inside of the body. MRI uses strong magnetic fields and non-ionising radiations to detect changes in living tissue. Memory point: CT = X-rays; MRI = magnetic field + non-ionising radiation.

How is leukemia (blood cancer) detected?

Leukemia is detected by blood and bone marrow tests that show an increased blood cell count. NEET traps students by saying counts 'decrease' — that is wrong. In leukemia the cell counts increase, which is why the tests look for a rise.

What is α-interferon and how does it treat cancer?

α-interferon is a biological response modifier. Tumor cells can hide from the immune system, so the patient is given α-interferon, which activates their own immune system and helps destroy the tumor. This is part of immunotherapy, not chemotherapy.

What is the difference between chemotherapy and radiotherapy?

In radiotherapy (radiation therapy), tumor cells are irradiated (given radiation) lethally while protecting nearby normal tissue. In chemotherapy, drugs are used to kill cancerous cells; many of these drugs cause side effects like hair loss and anemia. Most cancers use a combination of surgery, radiotherapy and chemotherapy.

Do chemotherapeutic drugs kill normal (non-cancerous) cells?

No. Chemotherapeutic drugs are used to kill cancerous cells, not non-cancerous ones. NEET 2025 used this exact wrong statement as a trap. Some drugs are specific for particular tumors, but their target is cancer cells.

⚠️ The NEET trap
Chemotherapeutic drugs are biological response modifiers that kill non-cancerous cells, and CT/MRI cannot detect internal cancers.
CT and MRI DO detect cancers of internal organs. Chemotherapeutic drugs kill CANCEROUS cells. The biological response modifier is α-interferon (not chemo drugs), which activates the immune system to destroy the tumor.
🧠 BRM = α-interferon, NOT chemo drugs. Chemo kills cancer cells, never normal cells.

Real NEET questions

NEET 2025

Which are correct: A. Computed tomography and magnetic resonance imaging detect cancers of internal organs. B. Chemotherapeutics drugs are used to kill non-cancerous cells. C. α-interferon activate the cancer patients' immune system and helps in destroying the tumour. D. Chemotherapeutic drugs are biological response modifiers. E. In the case of leukemia blood cell counts are decreases.

A · C and D only
B · A and C only
C · B and D only
D · D and E only
Solution: A is correct: CT and MRI detect cancers of internal organs. C is correct: α-interferon is a biological response modifier that activates the patient's immune system and helps destroy the tumor. B is wrong (chemo drugs kill CANCEROUS cells), D is wrong (α-interferon, not chemo drugs, is the biological response modifier), and E is wrong (in leukemia blood cell counts INCREASE). So only A and C are correct — option (B).
NEET 2021

Now a days it is possible to detect the mutated gene causing cancer by allowing radioactive probe to hybridise its complementary DNA in a clone of cells, followed by its detection using autoradiography because:

A · mutated gene does not appear on a Photographic film as the probe has no complementarity with it
B · mutated gene does not appear on Photographic film as the probe has complementarity with it
C · mutated gene partially appears on a photographic film
D · mutated gene completely and clearly appears on a photographic film.
Solution: The radioactive probe is complementary to the normal gene. Where the gene is mutated, the probe cannot base-pair (hybridise) with it because there is no complementarity, so no radioactive signal is recorded and that spot does not appear on the autoradiograph. This molecular-biology technique detects genes that predispose to cancer. Hence option (A).

Solved Human Health and Diseases NEET PYQs

Try the real previous-year questions from this chapter — each with the answer and a full solution.

See all 45 Human Health and Diseases NEET PYQs ›
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Frequently asked

What are the three main methods of cancer detection in NCERT?

Biopsy with histopathological study, blood and bone marrow tests (for increased cell count in leukemias), and imaging techniques — radiography (X-ray), CT and MRI. Antibodies against cancer-specific antigens and molecular biology techniques are also used.

What are the common approaches for cancer treatment?

The common approaches are surgery, radiation therapy (radiotherapy) and immunotherapy. Chemotherapy uses drugs to kill cancer cells. Most cancers are treated by a combination of surgery, radiotherapy and chemotherapy.

Which imaging uses non-ionising radiation, CT or MRI?

MRI uses strong magnetic fields and non-ionising radiations. CT uses X-rays, which are ionising. This difference is a common NEET point.

Why are cancer patients given α-interferon?

Tumor cells can avoid detection and destruction by the immune system. α-interferon is a biological response modifier that activates the patient's immune system so it can destroy the tumor.

What side effects do chemotherapy drugs cause?

Many chemotherapeutic drugs cause side effects such as hair loss and anemia. Some drugs are specific for particular tumors, but they target cancer cells, not normal cells.